Nimesulide is a popular NSAID and available in various forms including tablets, suppositories, water-soluble powders, and topical gels.

It is an analgesic and antipyretic in action, apart from its anti inflammatory action. Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a sulfonanilide moiety as the acidic group. It is absorbed rapidly and completely after oral administration.

Working
It acts by inhibiting the release of tumour necrosis factor-alpha, acts as a competitive inhibitor of histamine release and reduces superoxide anion formation

Dosage
Adults: 100 mg twice daily
Children: 5mg/kg of body weight in 2 or 3 divided doses.

Contra- Indications: Hypersensitivity, active peptic ulcer disease, hepatic impairment

Side Effects
The drug has certain side effects, that can affect individuals in different ways. The following are some of the side effects, that are often associated with the drug:

• Diarrhoea
• Vomiting
• Skin rash
• Pruritis
• Dizziness
• Headache

Women should use the drug with caution during lactation and it is contraindicated during pregnancy.

Brands